Pharmacologic intervention with alagebrium directly targets the biochemical pathway leading to the stiffness of the cardiovascular system. Removal of the AGEs by cleavage of the abnormal crosslinking bonds has been associated with diminished inflammatory and sclerotic signaling pathways. These pathways are responsible for the deposition of abnormal amounts of matrix proteins that physically stiffen tissues. The presence of AGE crosslinks also renders tissues and organs less susceptible to normal turnover thus enhancing the presence of these abnormal bonds on various molecules. Importantly, alagebrium does not disrupt the natural carbohydrate modification to proteins, intra-molecular crosslinking or peptide bonds that are responsible for maintaining the normal integrity of the collagen chain. Thus, normal structure and function is preserved while abnormal crosslinking is reduced.
Alteon said that it had selected ALT-711 as its lead AGE-breaker based on preclinical results in its annual report for the year 1997 and that it was preparing an IND filing.
In 2006 Alteon merged with a company called HaptoGuard that had cash and a potential diagnostic test for haptoglobin; as part of the merger Genentech, which held preferred shares in Alteon, converted their shares to common ones and received the right to get milestone payments and royalties on sales of alagebrium, and option rights to license ALT-2074. In 2007, the company changed its name to Synvista Therapeutics, Inc. Synvista announced that it was terminating clinical trials of alagebrium in January 2009 in order to focus on the diagnostic test and another clinical candidate SYI-2074 (formerly ALT-2074). The company seems to have discontinued operations and their website is no longer available.
711 (thiazolium chloride, aka alagebrium) is a protein glycation breaker. This chemical is very unique in that is the most powerful known “glycation breaker”, meaning that it can break the molecule that results when a glucose molecule bonds with a protein molecule. This is the process that is responsible for hardened arteries, wrinkly skin as well as many of the other hallmarks of the aging process. More description coming soon. The latter description is for informational purposes only and is based on published, double blind, placebo controlled research and has been published in a reputable medical journal. THIS PRODUCT IS INTENDED FOR RESEARCH PURPOSES ONLY. INGESTION CAN BE HAZARDOUS.